The mechanism of classical food allergy involves the release of inflammatory mediators after IgE antibodies bind to a mast cell. The sequence of events is as follows:
– Food antigen stimulates a class of lymphocytes called Th2 helper T cells
– These Th2 helper T cells secrete cytokines that instruct B lymphocytes to produce antigen-specific IgE antibodies
– IgE antibodies bind to mast cells and stimulate the release of inflammatory mediators, including histamine
– Inflammation is caused, producing classical allergic symptoms such as sneezing, watery eyes, itching, rashes, difficulty breathing etc
What is food intolerance?
Food intolerance is essentially an abnormal reaction to certain foods which can manifest itself in a number of ways.
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